THE EFFECT OF SULFUR MUSTARD ON GLUCOSE PHOSPHORYLATING ENZYMES AND LIVER CELLS IN MALE RATS
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Abstract:
A significant decrease of hepatic high-Km glucose- phosphorylating enzyme glucokinase (ATP- D- glucose 6- phosphotransferase, EC 2.7. 1.2, GK) and low-Km hexokinases (EC 2.7. 1.1. HK) activities were noticed in liver treated with 2, 2'- dichlorodiethyl sulfide (sulfur mustard, HD) when injectedinteraperitoneally to male rats in 114 LD50. This decrease occurred 1.5 to 5.5 hours after the injection. Simultaneously, a significant decrease in concentration of soluble protein and glycogen was also noted after2 hours. In addition some morphological changes on liver cells were noticed
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volume 1 issue 5
pages -
publication date 1990-11-01
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